Wise, true, and snarky art director India Amos is trying to hire an assistant. But oh, the horrors she's seen! Read all about it here.
All I can say is: People! Get a clue! Proof your resume and cover letter--multiple times! Ask friends to proof your documents, too. Better yet, hire someone to edit, or completely overhaul, your resume. Use some common sense, pay attention to detail, and spend a little time learning something about the company to which you are applying (for example, how to spell its name). This is not a climate in which employers are going to be forgiving for slackness. There are still jobs to be had, but not for the people who don't put a lot of effort into honing their presentations.